Idiopathic multicentric Castleman disease (iMCD)

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An iMCD patient in a white sweater is ready to take the next step with Sylvant.

Idiopathic multicentric Castleman disease (iMCD)

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An iMCD patient in a blue shirt is optimistic about the outcome of timely iMCD treatment.

Idiopathic multicentric Castleman disease (iMCD)

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Two iMCD patients look at a tablet together and discuss iMCD and Sylvant.

SYLVANT® (siltuximab) is a targeted therapy that has been approved by the US Food and Drug Administration (FDA) and recommended by the National Comprehensive Cancer Network® (NCCN®) for the treatment of iMCD.

  • BITSTAMP TRADEVIEW

    SYLVANT is the only targeted treatment for iMCD that binds with IL-6, a protein that is elevated in most patients, to help fight back against this rare disease.

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    The SYLVANT study was the largest one of its kind in iMCD. Its safety and effectiveness have been studied for more than 7 years. That’s why it’s the guideline-preferred treatment for iMCD.

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    Our experts at Patient Connect can help make your medication affordable, set up reminders so that you never miss a dose, and answer any questions you may have.

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  • SHIB MAGAZINE

    Get access to an interactive guide that can help you track your symptoms so that you can have a productive discussion with your doctor.

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    An iMCD patient discusses Sylvant with her doctor.
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Living with iMCD can be tough, but having a better understanding about this mysterious disease can help. Get information about SYLVANT, lifestyle tips, patient stories, and more.

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Are you an iMCD patient or caregiver?*
Have you been prescribed SYLVANT® (siltuximab) for the treatment of iMCD?*
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SYLVANT® (siltuximab) is a prescription medicine used to treat people with multicentric Castleman’s disease (MCD) who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection. It is not known if SYLVANT is safe and effective in children.

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SYLVANT® (siltuximab) is a prescription medicine used to treat people with multicentric Castleman’s disease (MCD) who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection. It is not known if SYLVANT is safe and effective in children.

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Do not take SYLVANT if you have had a severe allergic reaction to siltuximab or any of the ingredients in SYLVANT. See the Patient Information for a complete list of ingredients in SYLVANT.

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Infections. SYLVANT may lower your ability to fight infections. Tell your healthcare provider right away if you have any signs or symptoms of an infection during treatment with SYLVANT.

Infusion and allergic reactions. If you have an infusion or allergic reaction while receiving SYLVANT, your healthcare provider will stop your infusion and treat your reaction. If you have a severe infusion or allergic reaction, your healthcare provider may stop your treatment completely. Tell your healthcare provider or get medical help right away if you have any of these symptoms during or after your infusion of SYLVANT:

  • back pain
  • chest pain or tightness
  • nausea and vomiting
  • flushing
  • redness
  • irregular heart beat (palpitations)
  • trouble breathing
  • wheezing
  • dizziness or light-headedness
  • swelling of the lips
  • skin rash
  • headache
  • itching

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rash, itching, upper respiratory tract infection, swelling, weight gain, and increased blood level of uric acid.

These are not all the possible side effects of SYLVANT. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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  • have an infection. You should not take SYLVANT if you have a severe infection.
  • have had a recent vaccination or are scheduled to receive any vaccinations. You should not receive a live vaccine during your treatment with SYLVANT.
  • have or have had any stomach or bowel (intestine) problems, such as diverticulitis or ulcers. Tell your healthcare provider if you have any pain or discomfort in your stomach.
  • are pregnant or plan to become pregnant. It is not known if SYLVANT will harm your unborn baby. You should not become pregnant while receiving treatment with SYLVANT. Females who are able to become pregnant should use effective birth control during treatment with SYLVANT and for 3 months after stopping treatment.
  • are breastfeeding or plan to breastfeed. It is not known if SYLVANT passes into your breast milk. You and your healthcare provider should decide if you will take SYLVANT or breastfeed. You should not do both.

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including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Please see full Prescribing Information for additional Important Safety Information.